Achieving high singlet-oxygen generation by applying the heavy-atom effect to thermally activated delayed fluorescent materials.

Abstract

A bromine-substituted thermally activated delayed fluorescent (TADF) molecule AQCzBr2 is designed with both small singlet-triplet splitting (ΔEST) and increased spin-orbit coupling (SOC) to boost intersystem crossing (ISC) for singlet oxygen generation. AQCzBr2 nanoparticles (NPs) demonstrate high productivity of singlet oxygen generation (ΦΔ = 0.91) which allows highly efficient photodynamic therapy toward cancer cells.

• Authors: Ya-Fang Xiao, Jia-Xiong Chen, Wen-Cheng Chen, Xiuli Zheng, Chen Cao, Jihua Tan, Xiao Cui, Zhanxiang Yuan, Shaomin Ji, Guihong Lu, Weimin Liu, Pengfei Wang, Shengliang Li, Chun-Sing Lee
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 57 Issue 40 Pg. 4902-4905 (May 18 2021) ISSN: 1364-548X [Electronic] England
• PMID: 33870972 (Publication Type: Journal Article)