Ready-to-Use Micronized Human Acellular Dermal Matrix to Accelerate Wound Healing in Diabetic Foot Ulcers: A Prospective Randomized Pilot Study.

Abstract

OBJECTIVE:

To examine and report clinical outcomes of a ready-to-use micronized dermal matrix for diabetic foot ulcers (DFUs) and compare it to treatment with conventional negative-pressure wound therapy (NPWT) only.

METHODS:

The researchers randomly allocated 30 DFUs Wagner grade 2 or higher from 30 adult patients into two groups. The control group (n = 15) was treated with conventional NPWT, and the experimental group (n = 15) was treated with micronized dermal matrix and NPWT. The researchers evaluated the following outcomes: granulation tissue formation, proportion of patients with closed or granulated wounds at 42 and 120 days, achievement of complete wound healing in the 6 months of follow-up, and intervals from enrollment to final surgical procedures.

RESULTS:

All 15 wounds treated with the micronized matrix showed healthy granulation tissue without noticeable complications during follow-up. At 42 days, 46.7% of wounds in the experimental group had closed compared with 28.6% in the conventional NPWT group (P = .007). At 120 days, 86.7% of the experimental group had completely closed wounds, compared with 57.1% in the conventional therapy group (P = .040). During the 6-month follow-up period, 93.3% of the experimental group achieved complete wound healing compared with 85.7% of the conventional therapy group (P = .468).

CONCLUSIONS:

The healing outcomes for DFUs in the experimental group were superior when micronized matrix treatment was combined with NPWT.

• Authors: Hyung Min Hahn, Dong Hwan Lee, Il Jae Lee
• Journal: Advances in skin & wound care (Adv Skin Wound Care) Vol. 34 Issue 5 Pg. 1-6 (May 01 2021) ISSN: 1538-8654 [Electronic] United States
• PMID: 33852465 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Topics

• Acellular Dermis (standards, statistics & numerical data)
• Aged
• Diabetic Foot (complications, drug therapy)
• Female
• Humans
• Male
• Middle Aged
• Negative-Pressure Wound Therapy (methods, statistics & numerical data)
• Pilot Projects
• Prospective Studies
• Republic of Korea
• Wound Healing (drug effects, physiology)