880 nm NIR-Triggered Organic Small Molecular-Based Nanoparticles for Photothermal Therapy of Tumor.

Abstract

Photothermal therapy (PTT) has received constant attention as an efficient cancer therapy method due to locally selective treatment, which is not affected by the tumor microenvironment. In this study, a novel 880 nm near-infrared (NIR) laser-triggered photothermal agent (PTA), 3TT-IC-4Cl, was used for PTT of a tumor in deep tissue. Folic acid (FA) conjugated amphiphilic block copolymer (folic acid-polyethylene glycol-poly (β-benzyl-L-aspartate)10, FA-PEG-PBLA10) was employed to encapsulate 3TT-IC-4Cl by nano-precipitation to form stable nanoparticles (TNPs), and TNPs exhibit excellent photothermal stability and photothermal conversion efficiency. Furthermore, the in vitro results showed TNPs display excellent biocompatibility and significant phototoxicity. These results suggest that 880 nm triggered TNPs have great potential as effective PTAs for photothermal therapy of tumors in deep tissue.

• Authors: Yunying Zhao, Zheng He, Qiang Zhang, Jing Wang, Wenying Jia, Long Jin, Linlin Zhao, Yan Lu
• Journal: Nanomaterials (Basel, Switzerland) (Nanomaterials (Basel)) Vol. 11 Issue 3 (Mar 18 2021) ISSN: 2079-4991 [Print] Switzerland
• PMID: 33803677 (Publication Type: Journal Article)