Tuberous sclerosis complex (
TSC) is an autosomal-dominant, multi-system,
neurocutaneous disorder characterized by
hamartomas in multiple organs. This study aimed to evaluate the clinical and paraclinical manifestations of children with
TSC. The clinical and paraclinical characteristics of 79 children with
TSC were evaluated and the possible correlations between the factors were calculated. Among the studied children which composed of 41 females (51.9%) and 38 males (48.1%),
skin manifestations as hypopigmented macules as well as the brain involvement as cortical tubers in all (100%) cases, seizure in 74 (93.7%), and sub-ependymal nodules in 73 (92.4%) patients were the most common findings. The renal
angiomyolipoma was diagnosed in 36 (70.6%) out of 51 patients.
Subependymal giant cell astrocytoma in 25 (3/54%) out of 46 patients,
retinal hamartoma in 15 (42.9%) out of 35 patients, and cardiac
rhabdomyoma in 17 (41.3%) out of 46 patients were diagnosed. Furthermore, 50 (63.3%) out of 79 patients had psychological disorders that had a significant correlation with the prevalence of
seizures (p = 0.002). Given the multi-systemic involvement of
TSC, it is necessary that all organs of the patients even without any related clinical symptom or sign be examined regularly for proper therapeutic intervention and prevent
disease progression. The growth of
hamartomas in the brain and kidneys can be life-threatening; therefore, these organs have more importance to be regularly followed up and examined.