Prediction of Disease Free Survival in Laryngeal and Hypopharyngeal Cancers Using CT Perfusion and Radiomic Features: A Pilot Study.

Abstract

(1) Purpose: The objective was to evaluate CT perfusion and radiomic features for prediction of one year disease free survival in laryngeal and hypopharyngeal cancer. (2) Method and Materials: This retrospective study included pre and post therapy CT neck studies in 36 patients with laryngeal/hypopharyngeal cancer. Tumor contouring was performed semi-autonomously by the computer and manually by two radiologists. Twenty-six radiomic features including morphological and gray-level features were extracted by an internally developed and validated computer-aided image analysis system. The five perfusion features analyzed included permeability surface area product (PS), blood flow (flow), blood volume (BV), mean transit time (MTT), and time-to-maximum (Tmax). One year persistent/recurrent disease data were obtained following the final treatment of definitive chemoradiation or after total laryngectomy. We performed a two-loop leave-one-out feature selection and linear discriminant analysis classifier with generation of receiver operating characteristic (ROC) curves and confidence intervals (CI). (3) Results: 10 patients (28%) had recurrence/persistent disease at 1 year. For prediction, the change in blood flow demonstrated a training AUC of 0.68 (CI 0.47-0.85) and testing AUC of 0.66 (CI 0.47-0.85). The best features selected were a combination of perfusion and radiomic features including blood flow and computer-estimated percent volume changes-training AUC of 0.68 (CI 0.5-0.85) and testing AUC of 0.69 (CI 0.5-0.85). The laryngoscopic percent change in volume was a poor predictor with a testing AUC of 0.4 (CI 0.16-0.57). (4) Conclusions: A combination of CT perfusion and radiomic features are potential predictors of one-year disease free survival in laryngeal and hypopharyngeal cancer patients.

• Authors: Sean Woolen, Apurva Virkud, Lubomir Hadjiiski, Kenny Cha, Heang-Ping Chan, Paul Swiecicki, Francis Worden, Ashok Srinivasan
• Journal: Tomography (Ann Arbor, Mich.) (Tomography) Vol. 7 Issue 1 Pg. 10-19 (03 2021) ISSN: 2379-139X [Electronic] Switzerland
• PMID: 33681460 (Publication Type: Journal Article)
• Copyright: © 2021 by the authors.

Topics

• Disease-Free Survival
• Humans
• Hypopharyngeal Neoplasms (diagnostic imaging, surgery)
• Neoplasm Recurrence, Local
• Perfusion
• Pilot Projects
• Retrospective Studies
• Tomography, X-Ray Computed