Abstract | BACKGROUND: The burden of antimicrobial resistance is high in solid organ transplant (SOT) recipients. Among Swiss SOT recipients, we assessed temporal trends of ESBL-producing Enterobacterales (ESBL-E), identified risk factors for ESBL-E, and assessed the impact of resistance on patient outcome. METHODS: Data from the Swiss Transplant Cohort Study (STCS), a nationwide prospective cohort of SOT-recipients, were analysed. Temporal trends were described for ESBL-detection among Escherichia coli and non-Escherichia coli. In a nested case-control study, cases with ESBL-E infection were 1:1 matched (by time since transplantation, organ transplant, pathogen) to controls infected with non-ESBL-E. Factors associated with resistance and with unfavourable 30-day outcome (death, infection relapse, graft loss) were assessed. RESULTS: From 2012 to 2018, we identified 1'212 infection episodes caused by Enterobacterales in 1'074 patients, thereof 11.4% (138/1'212) caused by ESBL-E. The proportion of ESBL-production among Escherichia coli remained stable over time (p = 0.93) but increased for non-E. coli (p = 0.02) Enterobacterales. In the case-control study (n = 102), antibiotic pre-treatment was independently associated with ESBL-production (aOR = 2.6, 95%-CI: 1.0-6.8, p = 0.046). Unfavourable outcome occurred in 24/51 (47%) cases and 9/51 (18%) controls (p = 0.003). Appropriate empiric antibiotic therapy was the only modifiable factor associated with unfavourable outcome. CONCLUSIONS: In Swiss SOT-recipients, proportion of infections with ESBL-producing non-E. coli Enterobacterales increased in recent years. Antibiotic pre-treatment represents a risk factor for ESBL-E. Improving appropriateness of empiric antibiotic treatment might be an important measure to reduce unfavourable outcome, which was observed in almost half of SOT-recipients with ESBL-E infections.
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Authors | Philipp Kohler, Aline Wolfensberger, Susanne Stampf, Andreas Brönnimann, Katia Boggian, Christian van Delden, Melody Favre, Cédric Hirzel, Nina Khanna, Stefan P Kuster, Oriol Manuel, Dionysios Neofytos, Silvio Ragozzino, Peter W Schreiber, Laura Walti, Nicolas J Mueller, Swiss Transplant Cohort Study |
Journal | Antimicrobial resistance and infection control
(Antimicrob Resist Infect Control)
Vol. 10
Issue 1
Pg. 50
(03 07 2021)
ISSN: 2047-2994 [Electronic] England |
PMID | 33678189
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- beta-Lactamases
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Topics |
- Adult
- Aged
- Anti-Bacterial Agents
(administration & dosage)
- Case-Control Studies
- Drug Resistance, Bacterial
- Enterobacteriaceae
- Enterobacteriaceae Infections
(complications, mortality)
- Escherichia coli Infections
- Female
- Graft Rejection
(microbiology)
- Humans
- Male
- Middle Aged
- Organ Transplantation
- Prospective Studies
- Risk Factors
- Switzerland
- Transplant Recipients
- beta-Lactamases
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