The Optimal Timing of Antiretroviral Therapy Initiation in HIV-Infected Patients with Cryptococcal Meningitis: A Multicenter Prospective Randomized Controlled Trial.

Abstract

The optimal timing of antiretroviral therapy (ART) initiation in human immunodeficiency virus (HIV)-infected patients with cryptococcal meningitis (HIV/CM) is controversial. We designed a clinical trial to inves-tigate the optimal timing for ART initiation in HIV/CM patients. This will be a multicenter, prospective, and randomized clinical trial. Each enrolled patient will be randomized into either the early ART arm or the deferred ART arm. We will compare the mortality and incident rates of immune reconstitution inflammatory syndrome between the two arms. We hope to elucidate the optimal timing for ART initiation in HIV/CM patients.

• Authors: Xiaolei Xu, Yanqiu Lu, Vijay Harypursat, Feng Sun, Ting Zhao, Yanming Zeng, Xiaoqing He, Yaokai Chen
• Journal: Acta medica Okayama (Acta Med Okayama) Vol. 75 Issue 1 Pg. 109-113 (Feb 2021) ISSN: 0386-300X [Print] Japan
• PMID: 33649622 (Publication Type: Clinical Trial Protocol)

Chemical References

• Anti-Retroviral Agents

Topics

• Adult
• Anti-Retroviral Agents (therapeutic use)
• Female
• HIV Infections (complications, drug therapy)
• Humans
• Male
• Meningitis, Cryptococcal (complications, drug therapy)
• Multicenter Studies as Topic
• Prospective Studies
• Randomized Controlled Trials as Topic
• Time Factors