Menarche in primary ovarian insufficiency after a month of hormone replacement therapy: a case report.

Abstract

BACKGROUND:

Gynecologic anomalies, including uterine agenesis and ovarian dysgenesis, are some of the several differential diagnoses in adolescent females with primary amenorrhea and delayed puberty. Primary ovarian insufficiency is reported in the clinical practice of reproductive endocrinology can be determined by conducting sex hormone tests to evaluate the hypothalamic-pituitary-ovarian axis. However, confirmation of Mullerian agenesis by image modalities can be extremely challenging. Once the diagnosis is established, breakthrough bleeding usually occurs 2 to 3 years after hormonal replacement therapy.

CASE PRESENTATION:

We report a case of a seventeen year old Taiwanese female, 46 XX karyotype, with ovarian dysgenesis and an initial tentative diagnosis of uterine agenesis who experienced a breakthrough bleeding after a month of hormonal replacement therapy.

CONCLUSIONS:

The breakthrough bleeding after a month of estrogen therapy in primary ovarian insufficiency is uncommon, and the diagnosis of the absent uterus can have an extensive psychological impact on patients and their families.

• Authors: Biwen Cheng
• Journal: Journal of medical case reports (J Med Case Rep) Vol. 15 Issue 1 Pg. 92 (Feb 22 2021) ISSN: 1752-1947 [Electronic] England
• PMID: 33618767 (Publication Type: Case Reports)

Chemical References

• Estrogens, Conjugated (USP)
• Medroxyprogesterone

Topics

• Adolescent
• Estrogens, Conjugated (USP) (therapeutic use)
• Female
• Hormone Replacement Therapy
• Humans
• Medroxyprogesterone (therapeutic use)
• Menarche (drug effects)
• Primary Ovarian Insufficiency (diagnosis, drug therapy)
• Taiwan (epidemiology)
• Time Factors
• Treatment Outcome
• Urogenital Abnormalities (diagnostic imaging)
• Uterus (abnormalities, diagnostic imaging)