Design and Evaluation of Sustained Release of Ornidazole by Dental Inserts.

Abstract

Aim & Background: Ornidazole is an antimicrobial drug used to treat certain types of vaginal, urinary tract, and interstitial infections. The study aims to formulate and evaluate the dental inserts by using a drug candidate to sustained drug release to improve patient compliance, reduce dosing frequency, reduce the risk of dose dumping, and avoid the first-pass metabolism. They have better therapeutic efficacy and fewer side effects.

METHODS:

The dental inserts were prepared using various polymers alone and in combination with the different ratios of polymers. The evaluation parameters like thickness, drug content, content uniformity, moisture reuptake, weight variation, swelling studies, and erosion studies of the optimized inserts were studied. The in-vivo studies were conducted to determine the reduction of pocket depth in human volunteers.

RESULTS:

The system containing ethylcellulose and hydroxyl methyl propyl cellulose K100M (4:1) formulation F6 was optimized because drug release was sustained up to 120 hrs concerning other formulations. Optimized formulation followed first-order kinetics and Peppas release kinetics via fickian diffusion. There was no swelling, itching, irritation, and no reduction in the pocket depth in in-vivo studies.

CONCLUSION:

The study concluded that dental inserts could extend the release of Ornidazole for many hours and also enhance bioavailability. Furthermore, they also help in avoiding the first-pass effect. In vivo studies' observations showed no itching, irritation, swelling, and pocket-depth reduction.

• Authors: Sunchu Harika, Y Shravan Kumar, Y Madhusudhan Rao, Pavani Sriram, Uma Shankar
• Journal: Current drug metabolism (Curr Drug Metab) Vol. 22 Issue 7 Pg. 572-580 ( 2021) ISSN: 1875-5453 [Electronic] Netherlands
• PMID: 33618642 (Publication Type: Journal Article)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Anti-Infective Agents
• Delayed-Action Preparations
• Dental Implants
• Hypromellose Derivatives
• Ornidazole
• ethyl cellulose
• Cellulose

Topics

• Anti-Infective Agents (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
• Biological Availability
• Cellulose (analogs & derivatives)
• Delayed-Action Preparations
• Dental Implants
• Drug Compounding
• Humans
• Hypromellose Derivatives
• Ornidazole (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)