Biologic behavior of resected BRCA-mutated pancreatic cancer: Comparison with sporadic pancreatic cancer and other BRCA-related cancers.

Abstract

BACKGROUND:

Since margin-negative resection is essential for the cure of pancreatic cancer (PC), early detection of PC is important. Although PC is the third most common cancer associated with BRCA1/2 mutations, clinical research regarding BRCA mutations in resected PC are rare. In this study, we investigated the oncologic characteristics of resected PC with BRCA mutation to suggest management strategies.

METHODS:

We retrospectively reviewed data from 493 patients who were confirmed to be pathogenic BRCA1/2 mutation carriers between January 2007 and December 2019. We investigated the oncologic characteristics of PC patients by comparing them with resected sporadic PC and other BRCA-related cancer groups (breast cancer, ovarian cancer, and others).

RESULTS:

Ten BRCA mutation carriers (2.0%) experienced PC, and PC onset was significantly later than that of BRCA-related breast cancer (age: breast vs. pancreas, 45.0 vs. 53.5 years, p = 0.050). Six patients underwent pancreatectomy and their long-term survival outcomes did not differ from those of sporadic PC patients (disease free survival: BRCA1/2 vs. sporadic, 10.0 months vs. 9.0 months, p = 0.504; overall survival: BRCA1/2 vs. sporadic, 29.0 months vs. 35.0 months, p = 0.520).

CONCLUSION:

BRCA-mutated PC occurs later than BRCA-mutated breast cancer. Active genetic testing to identify BRCA1/2 mutation carriers at the onset of breast cancer and continuous long-term surveillance of these patients can provide opportunities to detect BRCA-mutated PC at a resectable stage.

• Authors: Sung Hyun Kim, Ho Kyoung Hwang, Woo Jung Lee, Chang Moo Kang
• Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (Pancreatology) Vol. 21 Issue 3 Pg. 544-549 (Apr 2021) ISSN: 1424-3911 [Electronic] Switzerland
• PMID: 33612442 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 IAP and EPC. Published by Elsevier B.V. All rights reserved.

Chemical References

• BRCA1 Protein
• BRCA1 protein, human
• BRCA2 Protein
• BRCA2 protein, human
• Biomarkers, Tumor

Topics

• Adult
• Aged
• BRCA1 Protein (genetics)
• BRCA2 Protein (genetics)
• Biomarkers, Tumor (genetics)
• Breast Neoplasms (diagnosis, genetics)
• Case-Control Studies
• Early Detection of Cancer (methods)
• Female
• Follow-Up Studies
• Genetic Testing
• Humans
• Male
• Middle Aged
• Ovarian Neoplasms (diagnosis, genetics)
• Pancreatectomy
• Pancreatic Neoplasms (diagnosis, genetics, mortality, surgery)
• Retrospective Studies
• Survival Analysis
• Treatment Outcome