Strategies for synthesis of 1,2,4-triazole-containing scaffolds using 3-amino-1,2,4-triazole.

Abstract

1,2,4-Triazole-containing scaffolds are unique heterocyclic compounds present in an array of pharmaceuticals and biologically important compounds used in the drug-discovery studies against cancer cells, microbes, and various types of disease in the human body. This review article summarizes the pharmacological significance of the 1,2,4-triazole-containing scaffolds and highlights the latest strategies for the synthesis of these privileged scaffolds using 3-amino-1,2,4-triazole. This review stimulates further research to find new and efficient methodologies for accessing new 1,2,4-triazole-containing scaffolds which would be very useful for the discover of new drug candidates.

• Authors: Shima Nasri, Mohammad Bayat, Khudaidad Kochia
• Journal: Molecular diversity (Mol Divers) Vol. 26 Issue 1 Pg. 717-739 (Feb 2022) ISSN: 1573-501X [Electronic] Netherlands
• PMID: 33608844 (Publication Type: Journal Article, Review)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature.

Chemical References

• Heterocyclic Compounds
• Triazoles
• 1,2,4-triazole
• Amitrole

Topics

• Amitrole
• Heterocyclic Compounds
• Humans
• Triazoles