Predictive value of 4-Hydroxyglutamate and miR-149-5p on eclampsia.

Abstract

This research aimed at exploring the predictive value of 4-Hydroxyglutamate and miR-149-5p on eclampsia. Preeclampsia patients admitted to our hospital (n = 204), with 112 mild patients and 92 severe patients. Thereinto, pregnant women who underwent physical examination were regarded as a normal group (NG) (n = 100). Serum 4-Hydroxyglutamate levels and miR-149-5p in each group were detected. The serum 4-Hydroxyglutamate level in pregnant women in the NG was markedly lower than that in preeclampsia, while the miR-149-5p level was higher (p = 0.001). The serum 4-Hydroxyglutamate level in severe preeclampsia was higher than that in mild preeclampsia, while the miR-149-5p level was lower (p = 0.001). Partial thromboplastin time (APTT) and prothrombin time (PT) of preeclampsia patients were lower than those of the NG, while Fibrinogen (Fib) was higher (p = 0.001). With the aggravation of the condition of patients, PT, APTT decreased and Fib index increased. In preeclampsia patients, serum 4-Hydroxyglutamate was negatively correlated with PT and APTT, positively correlated with Fib content (p < 0.001); serum miR-149-5p was dramatically positively correlated with PT and APTT, negatively correlated with Fib content (p < 0.001). 4-Hydroxyglutamate and miR-149-5p were relevant to the occurrence time of preeclampsia; 4-Hydroxyglutamate, miR-149-5p and their combination could be used for preeclampsia diagnosis. According to the situation of newborn, they were divided into good and poor groups. The 4-Hydroxyglutamate level in the good group was lower than that in the poor group, while the miR-149-5p level was higher. The adverse prognosis of preeclampsia patients was predicted by 4-Hydroxyglutamate and miR-149-5p. 4-Hydroxyglutamate is highly expressed in preeclampsia, while miR-149-5p is low. Single and combined detection of 4-Hydroxyglutamate, miR-149-5p can be used for preeclampsia diagnosis and prediction.

• Authors: Xiaolan Zhao, Yujue Wang, Lingling Li, Jie Mei, Xun Zhang, Zhao Wu
• Journal: Experimental and molecular pathology (Exp Mol Pathol) Vol. 119 Pg. 104618 (04 2021) ISSN: 1096-0945 [Electronic] Netherlands
• PMID: 33582167 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier Inc. All rights reserved.

Chemical References

• Glutamates
• MIRN149 microRNA, human
• MicroRNAs
• hydroxyglutamic acid

Topics

• Adult
• Blood Coagulation
• Eclampsia (blood, diagnosis, genetics)
• Female
• Glutamates (blood, metabolism)
• Humans
• Infant, Newborn
• MicroRNAs (blood, genetics, metabolism)
• Predictive Value of Tests
• Pregnancy
• Prognosis
• ROC Curve