Nutritionally variant streptococci causing endophthalmitis associated with intravitreal anti-vascular endothelial growth factor injection.

Abstract

PURPOSE:

To describe the clinical course and microbial properties of the first two reported cases of nutritionally variant Streptococci (Granulicatella adiacens and Abiotrophia defectiva) endophthalmitis following intravitreal anti-vascular endothelial growth factor injection (IVI).

OBSERVATIONS:

A 74 year-old female developed Granulicatella adiacens endophthalmitis following IVI. The patient underwent a pars plana vitrectomy and visual acuity recovered to 20/30 in six weeks. Similarly, an 88 year-old male developed Abiotrophia defectiva endophthalmitis after IVI. After a pars plana vitrectomy, the visual acuity recovered to 20/60 at five weeks.

CONCLUSIONS AND IMPORTANCE:

Endophthalmitis due to Streptococcus species has traditionally resulted in uniformly poor visual outcomes. However, nutritionally variant Streptococci, now reclassified as Granulicatella and Abiotrophia species, appear to have a less aggressive clinical course and better visual acuity outcomes. To the authors' knowledge, these are the first reports of nutritionally variant Streptococci following IVI related endophthalmitis.

• Authors: Robert L Steinmetz, Carsten Z Steinmetz, Daniela P Reyes-Capo, H Logan Brooks, Jesse D Sengillo, Darlene Miller, Harry W Flynn Jr
• Journal: American journal of ophthalmology case reports (Am J Ophthalmol Case Rep) Vol. 21 Pg. 101019 (Mar 2021) ISSN: 2451-9936 [Electronic] United States
• PMID: 33553806 (Publication Type: Case Reports)
• Copyright: © 2021 Published by Elsevier Inc.