Classical Hodgkin lymphoma.

Abstract

Classical Hodgkin lymphoma is one of the more frequent lymphomas and is generally considered a highly curable disease with standard first-line chemotherapy and radiotherapy in some cases. Despite these outstanding results, major problems remain unresolved. First, there are still patients who will not be cured with front-line regimens and, second, many patients who are cured of classical Hodgkin lymphoma continue to die prematurely due to the late toxic effects of their therapy. Because the median age of patients with classical Hodgkin lymphoma is in the mid-30s, the disease's impact on the number of years lost from productive life is remarkable. In recent years, the gold standard of chemotherapy (often combined with radiotherapy) has changed, with the approval of immunotherapy mostly in relapse settings.

• Authors: Pauline Brice, Eric de Kerviler, Jonathan W Friedberg
• Journal: Lancet (London, England) (Lancet) Vol. 398 Issue 10310 Pg. 1518-1527 (10 23 2021) ISSN: 1474-547X [Electronic] England
• PMID: 33493434 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 Elsevier Ltd. All rights reserved.

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Combined Modality Therapy
• Disease-Free Survival
• Hodgkin Disease (drug therapy, radiotherapy)
• Humans
• Immunotherapy
• Neoplasm Recurrence, Local (drug therapy)