[Preoperative Imatinib Therapy Followed by Laparoscopic Local Gastrectomy for a Giant Gastric Gastrointestinal Stromal Tumor-A Case Report].

Abstract

A 55-year-old man complained of abdominal distention. Gastroscopy showed a submucosal tumor in the upper-third portion of the stomach, with a biopsy diagnosis of gastrointestinal stromal tumor(GIST). Because abdominal contrast- enhanced CT findings suspected the invasion of the tumor into the pancreatic tail, preoperative imatinib therapy was performed. After 2 weeks of treatment, the tumor had shrunk to 44% of its starting volume. Six months later, CT findings suggestive of the tumor invasion had disappeared. Therefore, the laparoscopic local resection of the stomach was performed. The postoperative course was uneventful. A pathological diagnosis was c-kit-positive GIST, with less than 5/50 HPF of mitotic counts. Imatinib was restarted 2 weeks after the operation. The patient is alive 8 months after the operation, with no obvious recurrence. Preoperative imatinib therapy can be a useful option for large GIST tumors.

• Authors: Michiko Inukai, Susumu Shibasaki, Kazumitsu Suzuki, Yasuhiro Tsuru, Kazuhiro Matsuo, Ai Goto, Kenichi Nakamura, Tsuyoshi Tanaka, Kenji Kikuchi, Koichi Suda, Kazuki Inaba, Ichiro Uyama
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 47 Issue 13 Pg. 2062-2064 (Dec 2020) ISSN: 0385-0684 [Print] Japan
• PMID: 33468801 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Imatinib Mesylate

Topics

• Antineoplastic Agents (therapeutic use)
• Gastrectomy
• Gastrointestinal Stromal Tumors (drug therapy, surgery)
• Humans
• Imatinib Mesylate (therapeutic use)
• Laparoscopy
• Male
• Middle Aged
• Neoplasm Recurrence, Local
• Stomach Neoplasms (drug therapy, surgery)