Kambakutaisoto Treatment for Children With Night Crying and Arousal Parasomnias Developed During Prolonged Hospitalization for Hematological and Oncological Diseases.

Abstract

OBJECTIVE:

The lack of an established treatment standard prompted an examination of whether kambakutaisoto, an herbal formula, is effective for non-rapid eye movement (NREM)-related parasomnias and night crying (provisionally defined as an infantile form of arousal parasomnia).

METHODS:

This study included 137 children aged median 4.1 years (range, 0.02-18.5) who were admitted for hematological and oncological diseases.

RESULTS:

Of 137, 3 children developed recurrent episodes of NREM-related parasomnias, and 3 developed night crying. The proportion of children with night-crying/parasomnia receiving invasive procedures was significantly higher than those without (100% vs. 47%, P = .013). All 6 children with night crying/parasomnia received kambakutaisoto at a dose of 0.13-0.22 g/kg per os and responded from the start of administration with a significant reduction in the number of episodes. No adverse effects were observed.

CONCLUSION:

Kambakutaisoto may be a safe and promising therapy for night crying and NREM-related parasomnias in children.

• Authors: Nozomu Kawashima
• Journal: Journal of child neurology (J Child Neurol) Vol. 36 Issue 7 Pg. 568-574 (06 2021) ISSN: 1708-8283 [Electronic] United States
• PMID: 33432853 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal

Topics

• Adolescent
• Child
• Child, Preschool
• Crying
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Hematologic Diseases (therapy)
• Hospitalization
• Humans
• Infant
• Male
• Medicine, Kampo
• Neoplasms (therapy)
• Parasomnias (diagnosis, drug therapy, etiology)
• Retrospective Studies