The Single-Cell Gel Electrophoresis Genotoxin Sensitivity Assay.

Abstract

The single-cell gel electrophoresis-based genotoxin sensitivity assay (GSA) is an ex vivo approach which enables to study the impact of a variety of dietary factors, occupational exposures, and diseases on the sensitivity of humans towards genotoxic chemicals which cause adverse health effects such as cancer, accelerated aging, and infertility.

• Authors: Franziska Ferk, Miroslav Mišík, Halh Al-Serori, Armen Nersesyan, Georg Wultsch, Siegfried Knasmueller
• Journal: Methods in molecular biology (Clifton, N.J.) (Methods Mol Biol) Vol. 2240 Pg. 1-12 ( 2021) ISSN: 1940-6029 [Electronic] United States
• PMID: 33423222 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• Mutagens

Topics

• Carcinogenicity Tests (methods)
• Carcinogens (toxicity)
• Cell Survival
• Cells, Cultured
• Comet Assay (methods)
• DNA Damage
• Humans
• Lymphocytes (drug effects)
• Mutagens (toxicity)
• Single-Cell Analysis (methods)