Limited resection vs. pancreaticoduodenectomy for primary duodenal adenocarcinoma: a systematic review and meta-analysis.

Abstract

It is well known that surgery is the mainstay treatment for duodenal adenocarcinoma. However, the optimal extent of surgery is still under debate. We aimed to systematically review and perform a meta-analysis of limited resection (LR) and pancreatoduodenectomy for patients with duodenal adenocarcinoma. A systematic electronic database search of the literature was performed using PubMed and the Cochrane Library. All studies comparing LR and pancreatoduodenectomy for patients with duodenal adenocarcinoma were selected. Long-term overall survival was considered as the primary outcome, and perioperative morbidity and mortality as the secondary outcomes. Fifteen studies with a total of 3166 patients were analyzed; 995 and 1498 patients were treated with limited resection and pancreatoduodenectomy, respectively. Eight and 7 studies scored a low and intermediate risk of publication bias, respectively. The LR group had a more favorable result than the pancreatoduodenectomy group in overall morbidity (odd ratio [OR]: 0.33, 95% confidence interval [CI] 0.17-0.65) and postoperative pancreatic fistula (OR: 0.13, 95% CI 0.04-0.43). Mortality (OR: 0.96, 95% CI 0.70-1.33) and overall survival (OR: 0.61, 95% CI 0.33-1.13) were not significantly different between the two groups, although comparison of the two groups stratified by prognostic factors, such as T categories, was not possible due to a lack of detailed data. LR showed long-term outcomes equivalent to those of pancreatoduodenectomy, while the perioperative morbidity rates were lower. LR could be an option for selected duodenal adenocarcinoma patients with appropriate location or depth of invasion, although further studies are required.

• Authors: Pipit Burasakarn, Ryota Higuchi, Souya Nunobe, Shingo Kanaji, Hidetoshi Eguchi, Ken-Ichi Okada, Tsutomu Fujii, Yuichi Nagakawa, Kengo Kanetaka, Hiroharu Yamashita, Suguru Yamada, Shinji Kuroda, Toru Aoyama, Takahiro Akahori, Kenji Nakagawa, Masakazu Yamamoto, Hiroki Yamaue, Masayuki Sho, Yasuhiro Kodera, Japan Duodenal Cancer Guideline Committee
• Journal: International journal of clinical oncology (Int J Clin Oncol) Vol. 26 Issue 3 Pg. 450-460 (Mar 2021) ISSN: 1437-7772 [Electronic] Japan
• PMID: 33386555 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)

Topics

• Adenocarcinoma (surgery)
• Anastomosis, Surgical
• Duodenal Neoplasms (surgery)
• Humans
• Pancreatectomy
• Pancreatic Neoplasms (surgery)
• Pancreaticoduodenectomy