Influence of HLDF Differentiation Factor on Nonspecific Invasive Breast Carcinoma in vitro.

Abstract

The study was carried out on samples of invasive breast carcinoma of no special type from 36 patients aged 48.0 to 62.8 years. The effect of HLDF on nonspecific invasive breast carcinoma was a decrease in the relative content of low-differentiated cells and an increase in the relative content of highly differentiated cells. HLDF did not have a cytotoxic effect leading to the death of low-differentiated cells but promoted promotes the acquisition of a higher degree of differentiation by them. A more pronounced effect of HLDF was observed in more aggressive metastasizing forms of neoplasia, which allows us to consider this differentiation factor as a candidate for use in the differentiation therapy of malignant neoplasms.

• Authors: A I Autenshlyus, I P Zhurakovsky, K I Davletova, A P Bogachuk, V V Lyakhovich, V M Lipkin
• Journal: Doklady. Biochemistry and biophysics (Dokl Biochem Biophys) Vol. 495 Issue 1 Pg. 289-291 (Nov 2020) ISSN: 1608-3091 [Electronic] United States
• PMID: 33368036 (Publication Type: Journal Article)

Chemical References

• Neoplasm Proteins
• cell differentiation factor 8.2-kDa

Topics

• Breast Neoplasms (drug therapy, metabolism, pathology)
• Cell Differentiation (drug effects)
• Female
• Humans
• In Vitro Techniques
• Middle Aged
• Mitosis (drug effects)
• Neoplasm Grading
• Neoplasm Proteins (pharmacology)
• Organ Culture Techniques