OCTA evaluation of treatment-naïve flat irregular PED (FIPED)-associated CNV in chronic central serous chorioretinopathy before and after half-dose PDT.

Abstract

BACKGROUND:

To qualitatively and quantitatively evaluate the features of treatment-naïve flat irregular pigment epithelial detachment (FIPED)-associated choroidal neovascularization (CNV) in chronic central serous chorioretinopathy (CSC) using swept-source (SS) optical coherence tomography angiography (OCTA) before and after half-dose photodynamic therapy (PDT).

METHODS:

Retrospective case series. The multimodal imaging data of the eyes with FIPED-associated CNV in chronic CSC were reviewed. The features of FIPED-associated CNVs were evaluated by SS-OCTA.

RESULTS:

Records of twenty-one patients (21 eyes) were reviewed. The mean age was 56.62 ± 6.87 years. After half-dose PDT, all patients have improved best spectacle-corrected visual acuity from 0.49 at baseline to 0.25 at 6-month visit, and subfoveal choroidal thickness decreased with subretinal fluids absorbed. By OCTA, the features of CNV at baseline included long filamentous linear vessels (21/21), branching into other large mature vessels with rare anastomoses (21/21); and/or a 'dead tree' appearance at the vessel's termini (20/21); and no perilesional hypointense halo (21/21). Compared to those at baseline, the mean vessel density of CNV showed no significant change at 1-,3-,6-month follow-up, while the mean area of CNV was significantly larger at the 6-month follow-up (p = 0.013).

CONCLUSIONS:

OCT angiography allows to qualitatively and quantitatively evaluate CNV in chronic CSC. The features of FIPED-associated CNV on OCTA illustrated its quiescent characteristic and further guided therapy. Half-dose PDT showed favorable effects on chronic CSC complicated with FIPED-associated CNV.

• Authors: Jingli Guo, Wenyi Tang, Sisi Xu, Wei Liu, Gezhi Xu
• Journal: Eye (London, England) (Eye (Lond)) Vol. 35 Issue 10 Pg. 2871-2878 (10 2021) ISSN: 1476-5454 [Electronic] England
• PMID: 33323982 (Publication Type: Journal Article)
• Copyright: © 2020. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.

Chemical References

• Photosensitizing Agents

Topics

• Central Serous Chorioretinopathy (drug therapy)
• Choroidal Neovascularization (drug therapy)
• Chronic Disease
• Fluorescein Angiography
• Humans
• Middle Aged
• Photochemotherapy
• Photosensitizing Agents (therapeutic use)
• Retrospective Studies
• Tomography, Optical Coherence
• Visual Acuity