Abstract | PURPOSE: MATERIALS AND METHODS: We conducted a systematic search in Embase®, Medline® and the Cochrane Central Register of Controlled Trials. Randomized controlled trials and nonrandomized controlled trials assessing the effect of any form of antimicrobial prophylaxis in patients with transurethral resection of bladder tumors on postoperative urinary tract infections or asymptomatic bacteriuria were included. Risk of bias was assessed using RoB 2.0 or the Newcastle-Ottawa Scale. Fixed and random effects meta-analyses were conducted. As a potential basis for a scoping review, we exploratorily searched Medline for risk factors for urinary tract infections after transurethral resection of bladder tumors. The protocol was registered on PROSPERO (CRD42019131733). RESULTS: Of 986 screened publications, 7 studies with 1,725 participants were included; the reported effect sizes varied considerably. We found no significant effect of antimicrobial prophylaxis on urinary tract infections: the pooled odds ratio of the random effects model was 1.55 (95% CI 0.73-3.31). The random effects meta-analysis examining the effect of antimicrobial prophylaxis on asymptomatic bacteriuria showed an OR of 0.43 (0.18-1.04). Risk of bias was moderate. Our exploratory search identified 3 studies reporting age, preoperative pelvic radiation, preoperative hospital stay, duration of operation, tumor size, preoperative asymptomatic bacteriuria and pyuria as risk factors for urinary tract infections following transurethral resection of bladder tumors. CONCLUSIONS:
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Authors | Kathrin Bausch, Florian S Halbeisen, Soheila Aghlmandi, Sarah U Sutter, Hannah Ewald, Christian Appenzeller-Herzog, Jan A Roth, Andreas F Widmer, Hans H Seifert |
Journal | The Journal of urology
(J Urol)
Vol. 205
Issue 4
Pg. 987-998
(Apr 2021)
ISSN: 1527-3792 [Electronic] United States |
PMID | 33284673
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Topics |
- Antibiotic Prophylaxis
- Bacteriuria
(prevention & control)
- Humans
- Postoperative Complications
(prevention & control)
- Urinary Bladder Neoplasms
(surgery)
- Urinary Tract Infections
(prevention & control)
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