Abstract | OBJECTIVE: Conflicting evidence exists regarding the effect of NSAIDs on the risk of Barrett's esophagus. The purpose of this study is to systematically assess this effect through a meta-analysis. METHODS: Accordingly, clinical studies on NSAID use and Barrett's esophagus risk were searched on PubMed, Embase, and the Cochrane Library. Following this, meta-analyses were conducted using the RevMan 5.3 software. The pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were used as the effect size. RESULTS: Seven eligible studies (one cohort study and six case-control studies) were included for the present meta-analysis by adopting a fixed-effect model, which demonstrated that NSAIDs could reduce Barrett's esophagus risk (OR: 0.84, 95%CI:0.75-0.94, P<0.05). Moreover, subgroup analyses done according to sex showed that NSAIDs could reduce Barrett's esophagus risk in females (OR 0.85; 95% CI 0.73-0.99; P = 0.04), without heterogeneity between studies (P = 1.00 and I2 = 0%). However, this relationship was not evident in males (OR 0.85; 95% CI 0.68-1.07; P = 0.16). CONCLUSIONS: Overall, this meta-analysis provided high quality evidence that use of NSAIDs is associated with a reduced risk of Barrett's esophagus. However, the presence of a sex-dependent difference remains to be clarified.
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Authors | Jinjia Zhang, Huadong Wu, Rongying Wang |
Journal | Clinics and research in hepatology and gastroenterology
(Clin Res Hepatol Gastroenterol)
Vol. 45
Issue 3
Pg. 101552
(May 2021)
ISSN: 2210-741X [Electronic] France |
PMID | 33268293
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | Copyright © 2020. Published by Elsevier Masson SAS. |
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Pharmaceutical Preparations
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Topics |
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Barrett Esophagus
(drug therapy, prevention & control)
- Cohort Studies
- Female
- Humans
- Male
- Odds Ratio
- Pharmaceutical Preparations
- Risk Factors
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