HTLV-2 infection in Manaus, Brazil: first description of HTLV-2c subtype in an urban area of the Western Amazon region.

Abstract

INTRODUCTION:

We investigated the prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection in patients with hematological diseases from the western Amazon region of Brazil.

METHODS:

Samples from 306 patients were submitted for the molecular diagnosis of HTLV-1/2 infection by real time PCR (qPCR), with amplification, sequencing, and phylogenetic analysis of the long terminal repeat (LTR) region.

RESULTS:

A 29-year-old male carrier of sickle cell anemia with a history of multiple blood transfusions was diagnosed with the HTLV-2c subtype.

CONCLUSIONS:

This study describes the first known occurrence of HTLV-2c in the urban area of Brazil's western Amazon region.

• Authors: Gemilson Soares Pontes, Hygor Halyson Figueiredo Ribeiro, Diana Mota Toro, José Pereira de Moura Neto, Victor Souza, Maria Edilene Martins de Almeida, Valdinete Alves do Nascimento, Cristovão Alves da Costa, Felipe Gomes Naveca, Mike Santos, Antonio Carlos Rosário Vallinoto
• Journal: Revista da Sociedade Brasileira de Medicina Tropical (Rev Soc Bras Med Trop) Vol. 54 Pg. e20200066 ( 2020) ISSN: 1678-9849 [Electronic] Brazil
• PMID: 33206874 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Brazil (epidemiology)
• HTLV-I Infections (diagnosis, epidemiology)
• HTLV-II Infections (diagnosis, epidemiology)
• Human T-lymphotropic virus 1 (genetics)
• Human T-lymphotropic virus 2 (genetics)
• Humans
• Male
• Phylogeny