Evaluating the effect of transplanting umbilical cord matrix stem cells on ischemic tolerance in an animal model of stroke.

Abstract

OBJECTIVE:

Stroke, a cerebrovascular disease, has been introduced as the second cause of death and physical disability in the world. Recently, cell-based therapy has been considered by the scientific community as a promising strategy for reducing ischemic damages. The stem cells of the umbilical cord release growth and neurotrophic factors. The remarkable properties of these cells are the reason why they were selected as a potential candidate in the present research.

METHODS:

In this study, the impact of transplanting umbilical cord stem cells on injuries resulting from ischemia was investigated. The male rats were categorized into three major. Using stereotaxic surgery, stem cells were injected to the right striatum of the brain. One week after transplantation, cerebral ischemic induction surgery was performed. The rats in the transplantation + ischemia group were separately divided into distinct sub-groups to explore the score of the neurological deficits, infarction volume, integrity of the blood-brain barrier, and brain edema.

RESULTS:

In this study, a significant decrease was observed in the neurological deficits of the transplantation + ischemia group compared with those of the control group. Similarly, the volume of infarction, the permeability of the blood-brain barrier, and edema were significantly reduced in the transplantation + ischemia group in comparison with those of the control group.

CONCLUSION:

The pretreatment of the transplanted umbilical cord stem cells in the striatum of ischemic rats possibly leads to restorative events, exerting a decreasing effect on cell death. Subsequently, these events may improve the motor ability and reduce ischemic injuries.

• Authors: Mahmoud Ramdan, Mohammad Reza Bigdeli, Sepideh Khaksar, Abbas Aliaghaei
• Journal: Neurological research (Neurol Res) Vol. 43 Issue 3 Pg. 225-238 (Mar 2021) ISSN: 1743-1328 [Electronic] England
• PMID: 33167823 (Publication Type: Journal Article)

Topics

• Animals
• Brain Ischemia
• Disease Models, Animal
• Humans
• Male
• Mesenchymal Stem Cell Transplantation (methods)
• Rats
• Rats, Wistar
• Stroke