Enhancement of tumor lethality of ROS in photodynamic therapy.

Abstract

In the process of photodynamic therapy (PDT) treatment of tumors, reactive oxygen species (ROS) plays a key role in destroying tumor tissues. However, traditional PDT often has limited ROS killing capacity due to hypoxia in the tumor microenvironment (TME) or obstruction by the ROS defense system, resulting in poor efficacy. Therefore, enhancing the killing effect of ROS on tumors is the core of enhancing the anti-tumor effect of PDT. In recent years, many studies have developed a series of strategies to enhance the ability of ROS to kill tumors in view of the limitations of the TME on PDT. This article summarizes the commonly used or innovative strategies in recent years, including not only frequently used methods for hypoxia in the TME but also innovative strategies to inhibit the ROS defense system.

• Authors: Lan Ming, Kai Cheng, Yu Chen, Rui Yang, Daozhen Chen
• Journal: Cancer medicine (Cancer Med) Vol. 10 Issue 1 Pg. 257-268 (01 2021) ISSN: 2045-7634 [Electronic] United States
• PMID: 33141513 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Chemical References

• Antioxidants
• Blood Substitutes
• Reactive Oxygen Species
• Hydrogen Peroxide
• Oxygen

Topics

• Animals
• Antioxidants (metabolism)
• Biomimetic Materials (therapeutic use)
• Blood Substitutes (therapeutic use)
• Humans
• Hydrogen Peroxide (metabolism)
• Neoplasms (drug therapy, metabolism, pathology)
• Neovascularization, Pathologic
• Oxidative Stress
• Oxygen (blood)
• Photochemotherapy (adverse effects)
• Reactive Oxygen Species (metabolism)
• Treatment Outcome
• Tumor Hypoxia
• Tumor Microenvironment