Abstract | OBJECTIVE: METHODS: The microemulsion method was used to form lipid bilayers to encapsulate Fe3O4 nanoparticles with superparamagnetism to form lipid magnetic balls, and KRAS antibodies were formed on the surface to form KRAS immune lipid magnetic balls. RESULTS: Compared with traditional EpCAM antibody-modified lipid magnetic balls, it can effectively improve the capture ability of colorectal cancer circulating tumor cells with KRAS mutation, the capture rate reaches 92.9%, and the capture results are consistent with clinical diagnosis and pathology. CONCLUSION: Our results showed that KRAS antibody-modified lipid magnetic balls can be used in the diagnosis and treatment of KRAS colorectal cancer.
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Authors | Chengbao Feng, Jingjing Wang, Xue Yang, Xuefang Zang, Haikun Zhou, Erying Zhang, Haifei Li, Bo Liu, Shumin Chen, Ying Wang, Peng Wang, Lixue Gao, Jinyan Liu |
Journal | Cancer management and research
(Cancer Manag Res)
Vol. 12
Pg. 10067-10075
( 2020)
ISSN: 1179-1322 [Print] New Zealand |
PMID | 33116863
(Publication Type: Journal Article)
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Copyright | © 2020 Feng et al. |