Once Weekly Application of Urea 40% and Bifonazole 1% Leads to Earlier Nail Removal in Onychomycosis.

Abstract

INTRODUCTION:

Onychomycosis is a chronic nail fungal infection resulting in nail damage and a decreased quality of life. Chemical avulsion of the nail with urea and bifonazole -removes fungally infected debris, increasing antifungal treatment efficacy and penetration. Previous clinical ob-servations describe patients who applied their urea and -bifonazole ointment less frequently, achieving earlier nail removal. In this study, we analyzed the relationship between duration of urea and bifonazole application and time to nail avulsion.

METHODS:

χ2 tests, multiple regression analysis, and ANOVA were performed to analyze the similarities between treatment regimens (daily, every 3 days, or once a week), association of regimens or patient characteristics to nail removal, and compare time to nail removal between each regimen, respectively.

RESULTS:

Daily application of ointment and sealing resulted in an average length of time (±SD) to nail removal of 18.7 days (±6.8 days); once every 3 days resulted in nail removal at 12.7 days (±6.2 days) and once per week at 11 days (±4.46 days) (p < 0.001). Age was the only patient factor that affected duration to nail removal.

CONCLUSION:

Once weekly application of ointment with sealing for a 1-week duration is associated with a decrease in time to complete chemical avulsion of the nail by approximately 1 week.

• Authors: Avner Shemer, Yossi Eshel, Aditya K Gupta, Renata Farhi, Eckart Haneke, Carlton Ralph Daniel, Kelly Foley, Emma M Quinlan
• Journal: Skin appendage disorders (Skin Appendage Disord) Vol. 6 Issue 5 Pg. 304-308 (Sep 2020) ISSN: 2296-9195 [Print] Switzerland
• PMID: 33088816 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 by S. Karger AG, Basel.