Efficacy and safety of combined immunotherapy and antiangiogenic therapy for advanced non-small cell lung cancer: A two-center retrospective study.

Abstract

BACKGROUND:

The synergistic effects of immunotherapy and antiangiogenic therapy in advanced non-small cell lung cancer (NSCLC) have been reported in both preclinical and clinical trials. Herein, we evaluated the preliminary efficacy and safety of combined immunotherapy and antiangiogenic therapy in patients with previously treated advanced NSCLC in a real-world setting.

METHODS:

We conducted a 2-center, retrospective study of previously treated advanced NSCLC patients who received any anti-programmed death-1 antibody combined with antiangiogenic agent between May 2018 and March 2020.

RESULTS:

In total, 57 patients were included in this study, and the objective response rate and disease control rate were 19.3% and 63.2%, respectively. The median progression-free survival (PFS) was 4.2 months (95% confidence interval [CI]: 3.2-5.2 months). Bone metastases (odds ratio [OR] not available; P < .01) and ≥ 3 treatment lines (OR 6.8; 95% CI: 1.6-29.6; P < .05) were independent negative predictors of objective response. Additionally, liver metastases (hazard ratio [HR] 3.7; 95% CI: 1.6-8.5; P < 0.01), poor performance status score (PS) (HR 3.4; 95% CI: 1.6-7.5; P < 0.01) and ≥ 3 treatment lines (HR 3.5; 95% CI: 1.7-7.4; P < 0.01) were found to be negative predictors of PFS. Eighty-nine percent of the patients experienced an adverse event.

CONCLUSIONS:

Metastatic sites (bone and liver), ≥3 treatment lines and poor PS were potential negative predictors of the efficacy of immunotherapy combined with antiangiogenic therapy for treating NSCLC. Further investigations and randomized controlled trials are needed.

• Authors: Junlin Yao, Zhengyang Wang, Jin Sheng, Huadi Wang, Liangkun You, Xudong Zhu, Hongming Pan, Weidong Han
• Journal: International immunopharmacology (Int Immunopharmacol) Vol. 89 Issue Pt A Pg. 107033 (Dec 2020) ISSN: 1878-1705 [Electronic] Netherlands
• PMID: 33039958 (Publication Type: Journal Article, Multicenter Study)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• Angiogenesis Inhibitors
• Immune Checkpoint Inhibitors
• PDCD1 protein, human
• Programmed Cell Death 1 Receptor

Topics

• Adult
• Aged
• Aged, 80 and over
• Angiogenesis Inhibitors (adverse effects, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Carcinoma, Non-Small-Cell Lung (drug therapy, immunology, secondary)
• China
• Female
• Humans
• Immune Checkpoint Inhibitors (adverse effects, therapeutic use)
• Immunotherapy (adverse effects)
• Lung Neoplasms (drug therapy, immunology, pathology)
• Male
• Middle Aged
• Pilot Projects
• Programmed Cell Death 1 Receptor (antagonists & inhibitors)
• Progression-Free Survival
• Retrospective Studies
• Risk Assessment
• Risk Factors
• Time Factors