Abstract | OBJECTIVES: The use of antithrombotic prophylaxis in women with recurrent pregnancy losses (RPL) remains controversial. METHODS: We performed meta-analysis of randomized controlled trials (RCTs) comparing low molecular weight heparin ( LMWH) versus No LMWH in women with or without hereditary thrombophilia and RPL. Twelve RCTs met our inclusion criteria and 2298 women were included in this meta-analysis. Our primary end point was live birth and odds ratio (OR) for live birth are reported. RESULTS: In women with thrombophilia the benefit of LMWH on live birth is not significant but heterogeneity of the studies is significant (OR, 2.09; 95 % CI, 0.58-7.57; p = 0.26; I2 = 86 %, p = 0.0001). Considering women without thrombophilia there is no benefit of LMWH in OR of live birth and data from studies have low heterogeneity (OR, 1.25; 95 % CI, 0.88-1.78; p = 0 0.21; I2 = 44 %, p = 0.07). CONCLUSIONS: Hold your needles in women with RPL. Probably in some hereditary thrombophilic defects LMWH has a positive effect on OR for live birth.
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Authors | Stergios Intzes, Marianthi Symeonidou, Konstantinos Zagoridis, Maria Stamou, Athina Spanoudaki, Emmanouil Spanoudakis |
Journal | Journal of gynecology obstetrics and human reproduction
(J Gynecol Obstet Hum Reprod)
Vol. 50
Issue 4
Pg. 101935
(Apr 2021)
ISSN: 2468-7847 [Electronic] France |
PMID | 33035720
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | Copyright © 2020 Elsevier Masson SAS. All rights reserved. |
Chemical References |
- Anticoagulants
- Heparin, Low-Molecular-Weight
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Topics |
- Abortion, Habitual
(blood, drug therapy)
- Anticoagulants
(administration & dosage)
- Female
- Heparin, Low-Molecular-Weight
(administration & dosage)
- Humans
- Live Birth
- Needles
- Odds Ratio
- Pregnancy
- Pregnancy Complications, Hematologic
(drug therapy)
- Publication Bias
- Randomized Controlled Trials as Topic
- Thrombophilia
(drug therapy)
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