Epithelioid leiomyosarcoma of the stomach. A case study of the intermediate filaments.

The intermediate filament typing of skeletal and smooth muscle tumors has shown that these neoplasms are characterized by the combined expression of desmin and vimentin intermediate filaments. A case of epithelioid leiomyosarcoma of the stomach was studied by conventional light microscopy and by indirect immunofluorescence using tissue-specific antibodies against intermediate filaments. The tumor cells labeled strongly with vimentin antibodies and were negative for desmin and prekeratin. This peculiar staining pattern may be the result of poor differentiation of the tumor cells with resultant loss of expression of desmin, or may be due to origin from a distinctive smooth muscle cell characterized by the exclusive expression of vimentin intermediate filaments.
AuthorsS Suster, M Huszar
JournalThe American journal of surgical pathology (Am J Surg Pathol) Vol. 11 Issue 7 Pg. 575-80 (Jul 1987) ISSN: 0147-5185 [Print] UNITED STATES
PMID3300387 (Publication Type: Case Reports, Journal Article)
  • Cytoskeleton (ultrastructure)
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Intermediate Filaments (ultrastructure)
  • Leiomyosarcoma (pathology, ultrastructure)
  • Microscopy, Electron
  • Middle Aged
  • Stomach Neoplasms (pathology, ultrastructure)

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