Comparison of the maternal and neonatal outcomes of pregnant women whose anemia was not corrected before delivery and pregnant women who were treated with intravenous iron in the third trimester.

Abstract

AIM:

Anemia is one of the most common problems of pregnancy. In this study, we aimed to compare the maternal and fetal outcomes in labor and delivery in women whose anemia was treated with intravenous iron and women who delivered with uncorrected anemia.

MATERIALS:

METHODS: This retrospective case-control study was carried out in a tertiary obstetric care center. Term (> 37 weeks), singleton, low-risk pregnant women who were admitted for delivery were evaluated. Seventy-two pregnant women who had intravenous ferric carboxymaltose treatment in the third trimester were compared with 72 women who were anemic (Hb < 10 g/dL) at the time Queryof admission for delivery.

RESULTS:

The groups were similar in terms of age, parity, and gestational age. The mean gestational age of the study group was 38.6 weeks. Their mean Hb of 8.2 ± 0.8 g/dL improved to 11.1 ± 1.3 g/dL prior birth. The mean Hb of the anemic group was 9.1 ± 0.5 g/dL upon admission for birth. The mean APGAR scores, admission to neonatal intensive care unit, and the rates of preterm delivery, small for gestational age, and low-birth weight infant were similar between groups. The primary cesarean section rate was significantly higher in anemic women (4.2% vs. 19.4%; p < 0.001) and the need for postpartum blood transfusion also decreased with iv iron treatment (8.3% vs. 29.2%; p = 0.02).

CONCLUSION:

Correction of anemia with intravenous ferric carboxymaltose in the third trimester does not significantly change neonatal outcomes but it is effective in reducing maternal morbidity.

• Authors: Z Asli Oskovi-Kaplan, Harun Kilickiran, Gul Nihal Buyuk, Sebnem Ozyer, H Levent Keskin, Yaprak Engin-Ustun
• Journal: Archives of gynecology and obstetrics (Arch Gynecol Obstet) Vol. 303 Issue 3 Pg. 715-719 (03 2021) ISSN: 1432-0711 [Electronic] Germany
• PMID: 32990783 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Ferric Compounds
• ferryl iron
• ferric carboxymaltose
• Maltose
• Iron

Topics

• Adult
• Anemia (diagnosis, drug therapy, epidemiology)
• Case-Control Studies
• Cesarean Section
• Female
• Ferric Compounds (administration & dosage, therapeutic use)
• Gestational Age
• Humans
• Infant
• Infant, Newborn
• Infant, Small for Gestational Age
• Injections, Intravenous
• Iron (administration & dosage, therapeutic use)
• Maltose (administration & dosage, analogs & derivatives, therapeutic use)
• Pregnancy
• Pregnancy Complications, Hematologic (blood, drug therapy, epidemiology)
• Pregnancy Outcome
• Pregnancy Trimester, Third
• Pregnant Women
• Retrospective Studies
• Turkey (epidemiology)