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NIR-Triggered Hyperthermal Effect of Polythiophene Nanoparticles Synthesized by Surfactant-Free Oxidative Polymerization Method on Colorectal Carcinoma Cells.

Abstract
In this work, polythiophene nanoparticles (PTh-NPs) were synthesized by a surfactant-free oxidative chemical polymerization method at 60 °C, using ammonium persulphate as an oxidant. Various physicochemical properties were studied in terms of field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), Fourier transform infra-red (FT-IR) spectroscopy, and differential scanning calorimetry (DSC)/thermogravimetric analysis (TGA). Photothermal performance of the as-synthesized PTh-NPs was studied by irradiating near infra-red of 808 nm under different concentration of the substrate and power supply. The photothermal stability of PTh-NPs was also studied. Photothermal effects of the as-synthesized PTh-NPs on colorectal cancer cells (CT-26) were studied at 100 µg/mL concentration and 808 nm NIR irradiation of 2.0 W/cm2 power. Our in vitro results showed remarkable NIR laser-triggered photothermal apoptotic cell death by PTh-NPs. Based on the experimental findings, it is revealed that PTh-NPs can act as a heat mediator and can be an alternative material for photothermal therapy in cancer treatment.
AuthorsDeval Prasad Bhattarai, Beom Su Kim
JournalCells (Cells) Vol. 9 Issue 9 (09 18 2020) ISSN: 2073-4409 [Electronic] Switzerland
PMID32962169 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Polymers
  • Thiophenes
  • ammonium peroxydisulfate
  • polythiophene
  • Ammonium Sulfate
Topics
  • Ammonium Sulfate (chemistry)
  • Animals
  • Antineoplastic Agents (chemical synthesis, pharmacology, radiation effects)
  • Apoptosis (drug effects)
  • Cell Line, Tumor
  • Cell Survival (drug effects)
  • Colon (drug effects, pathology)
  • Epithelial Cells (drug effects, pathology)
  • Infrared Rays
  • Mice
  • Nanoparticles (chemistry, radiation effects, ultrastructure)
  • Oxidation-Reduction
  • Photothermal Therapy (methods)
  • Polymerization
  • Polymers (chemical synthesis, pharmacology, radiation effects)
  • Thiophenes (chemical synthesis, chemistry, pharmacology, radiation effects)

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