Abstract |
In this work, polythiophene nanoparticles (PTh-NPs) were synthesized by a surfactant-free oxidative chemical polymerization method at 60 °C, using ammonium persulphate as an oxidant. Various physicochemical properties were studied in terms of field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), Fourier transform infra-red (FT-IR) spectroscopy, and differential scanning calorimetry (DSC)/thermogravimetric analysis (TGA). Photothermal performance of the as-synthesized PTh-NPs was studied by irradiating near infra-red of 808 nm under different concentration of the substrate and power supply. The photothermal stability of PTh-NPs was also studied. Photothermal effects of the as-synthesized PTh-NPs on colorectal cancer cells (CT-26) were studied at 100 µg/mL concentration and 808 nm NIR irradiation of 2.0 W/cm2 power. Our in vitro results showed remarkable NIR laser-triggered photothermal apoptotic cell death by PTh-NPs. Based on the experimental findings, it is revealed that PTh-NPs can act as a heat mediator and can be an alternative material for photothermal therapy in cancer treatment.
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Authors | Deval Prasad Bhattarai, Beom Su Kim |
Journal | Cells
(Cells)
Vol. 9
Issue 9
(09 18 2020)
ISSN: 2073-4409 [Electronic] Switzerland |
PMID | 32962169
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Polymers
- Thiophenes
- ammonium peroxydisulfate
- polythiophene
- Ammonium Sulfate
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Topics |
- Ammonium Sulfate
(chemistry)
- Animals
- Antineoplastic Agents
(chemical synthesis, pharmacology, radiation effects)
- Apoptosis
(drug effects)
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Colon
(drug effects, pathology)
- Epithelial Cells
(drug effects, pathology)
- Infrared Rays
- Mice
- Nanoparticles
(chemistry, radiation effects, ultrastructure)
- Oxidation-Reduction
- Photothermal Therapy
(methods)
- Polymerization
- Polymers
(chemical synthesis, pharmacology, radiation effects)
- Thiophenes
(chemical synthesis, chemistry, pharmacology, radiation effects)
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