Abstract | BACKGROUND: METHODS: A standard meta-analysis protocol was developed and after performing a comprehensive literature search in MEDLINE, Cochrane, and International Clinical Trial Registry Platform (ICTRP), reviewers assessed eligibility and extracted data from three relevant articles. A random-effects model was used to estimate the pooled effect size as the mean difference in Visual Analouge Scale (VAS) score, serum hsCRP, serum Amyloid A, and risk ratio for global assessment between the groups. Quality assessment was done using the risk of bias assessment tool and summary of findings was prepared using standard Cochrane methodology with GradePro GDT. RESULTS: Treatment with canakinumab showed a mean reduction of VAS score by 14.59 mm [95% CI - 19.42 to - 9.77], serum hsCRP by 15.36 mg/L [95% CI 1.62-29.11], serum Amyloid A by 67.18 mg/L [95% CI 17.06-117.31], and improvement in patient global assessment (RR = 1.478; 95% CI 1.29-1.67) and physician global assessment (RR = 1.44; 95% CI 1.28-1.61). The probability that future studies may have a mean difference in VAS score less than zero has been calculated to be 27.3% using a cumulative distribution function (CDF) calculator. CONCLUSION:
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Authors | Monalisa Jena, Amruta Tripathy, Archana Mishra, Rituparna Maiti |
Journal | Inflammopharmacology
(Inflammopharmacology)
Vol. 29
Issue 1
Pg. 35-47
(Feb 2021)
ISSN: 1568-5608 [Electronic] Switzerland |
PMID | 32918702
(Publication Type: Comparative Study, Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
- Antibodies, Monoclonal, Humanized
- IL1B protein, human
- Interleukin-1beta
- Serum Amyloid A Protein
- Triamcinolone
- canakinumab
- C-Reactive Protein
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Topics |
- Antibodies, Monoclonal, Humanized
(administration & dosage, pharmacology)
- Arthritis, Gouty
(drug therapy, immunology, physiopathology)
- C-Reactive Protein
(metabolism)
- Humans
- Interleukin-1beta
(immunology)
- Serum Amyloid A Protein
(metabolism)
- Treatment Outcome
- Triamcinolone
(pharmacology)
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