Sulfated polymannuroguluronate TGC161 ameliorates leukopenia by inhibiting CD4+ T cell apoptosis.

Abstract

Polysaccharides have aroused considerable interest due to their diverse biological activities and low toxicity. In this study, we evaluated the effect of marine polysaccharide sulfated polymannuroguluronate (TGC161) on the leukopenia induced by chemotherapy. It is found that TGC161 ameliorates the leukopenia. Besides, TGC161 would promote CD4+ T cell differentiation and maturation in the thymus, but does not have a significant effect on precursor cells in bone marrow. Furthermore, TGC161 inhibits CD4+ T cell apoptosis in vitro. Collectively, our findings offer a natural and harmless polysaccharide to ameliorate leukopenia.

• Authors: Chuanqin Shi, Wenwei Han, Meifang Zhang, Ruochen Zang, Kaixin Du, Li Li, Ximing Xu, Chunxia Li, Shixin Wang, Peiju Qiu, Huashi Guan, Jinbo Yang, Shuai Xiao, Xin Wang
• Journal: Carbohydrate polymers (Carbohydr Polym) Vol. 247 Pg. 116728 (Nov 01 2020) ISSN: 1879-1344 [Electronic] England
• PMID: 32829850 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Chemical References

• Polysaccharides
• sulfated polymannuroguluronate

Topics

• Animals
• Apoptosis (drug effects)
• CD4-Positive T-Lymphocytes (drug effects, immunology)
• Leukopenia (immunology, pathology, prevention & control)
• Male
• Mice
• Mice, Inbred C57BL
• Polysaccharides (pharmacology)