Abstract | PURPOSE: To report a case of microsporidia (Encephalitozoon hellem) keratoconjunctivitis acquired through avian transmission in an immunocompetent adult, diagnosed by metagenomic deep sequencing (MDS), and confirmed by polymerase chain reaction. METHODS: A case report. RESULTS: An 18-year-old woman was referred with unilateral keratoconjunctivitis unresponsive to topical and systemic therapy after exposure to birdcage debris. Slit-lamp examination of the left eye revealed a follicular papillary reaction of the palpebral conjunctiva and multiple corneal punctate epithelial opacities that stained minimally with fluorescein. In vivo confocal microscopy revealed bright double-walled structures and smaller bright round structures in the superficial epithelial debris and epithelium. Molecular diagnosis with MDS of E. hellem was confirmed by polymerase chain reaction. Clinical resolution and normalization of in vivo confocal microscopy was observed after a 6-week course of topical azithromycin. The patient elected a 3-week course of topical voriconazole 1% for definitive antimicrosporidial treatment, with no evidence of persistent infection 1 month later. CONCLUSIONS:
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Authors | Kevin K Ma, Benyam Kinde, Thuy Doan, Deborah S Jacobs, Stephan Ong Tone |
Journal | Cornea
(Cornea)
Vol. 40
Issue 2
Pg. 242-244
(Feb 01 2021)
ISSN: 1536-4798 [Electronic] United States |
PMID | 32826651
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved. |
Chemical References |
- Anti-Bacterial Agents
- Antifungal Agents
- Azithromycin
- Voriconazole
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Topics |
- Adolescent
- Anti-Bacterial Agents
(therapeutic use)
- Antifungal Agents
(therapeutic use)
- Azithromycin
(therapeutic use)
- Drug Therapy, Combination
- Encephalitozoon
(genetics, isolation & purification)
- Eye Infections, Fungal
(diagnosis, drug therapy, microbiology)
- Female
- Humans
- Immunocompetence
- Keratoconjunctivitis
(diagnosis, drug therapy, microbiology)
- Metagenomics
- Microscopy, Confocal
- Microsporidiosis
(diagnosis, drug therapy, microbiology)
- Polymerase Chain Reaction
- Voriconazole
(therapeutic use)
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