Facile synthesis of hollow mesoporous nickel sulfide nanoparticles for highly efficient combinatorial photothermal-chemotherapy of cancer.

Abstract

Traditional techniques for the synthesis of nickel sulfide (NiS) nanoparticles (NPs) always present drawbacks of morphological irregularity, non-porous structure and poor long-term stability, which are extremely unfavorable for establishing effective therapeutic agents. Here, a category of hollow mesoporous NiS (hm-NiS) NPs with uniform spherical structure and good aqueous dispersity were innovatively developed based on a modified solvothermal reaction technique. Upon the successful synthesis of hm-NiS NPs, dopamine was seeded and in situ polymerized into polydopamine (PDA) on the NP surface, followed by functionalization with thiol-polyethylene glycol (SH-PEG) and encapsulation of the chemotherapeutic drug, doxorubicin (DOX), to form hm-NiS@PDA/PEG/DOX (NiPPD) NPs. The resultant NiPPD NPs exhibited a decent photothermal response and stability, attributed to the optical absorption of the hm-NiS nanocore and PDA layer in the near-infrared (NIR) region. Furthermore, stimulus-responsive drug release was achieved under both acidic pH conditions and NIR laser irradiation, owing to the protonation of -NH2 groups in the DOX molecules and local thermal shock, respectively. Lastly, a strong combinatorial photothermal-chemotherapeutic effect was demonstrated for tumor suppression with minimal systemic toxicity in vivo. Collectively, this state-of-the-art paradigm may provide useful insights to deepen the application of hm-NiS NPs for disease management and precision medicine.

• Authors: Ruihao Yang, Ruidong Li, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
• Journal: Journal of materials chemistry. B (J Mater Chem B) Vol. 8 Issue 34 Pg. 7766-7776 (09 14 2020) ISSN: 2050-7518 [Electronic] England
• PMID: 32744285 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Indoles
• Polymers
• polydopamine
• Polyethylene Glycols
• Nickel
• Doxorubicin
• nickel sulfide

Topics

• Cell Line
• Chemistry Techniques, Synthetic
• Combined Modality Therapy
• Doxorubicin (chemistry)
• Humans
• Indoles (chemistry)
• Nanomedicine (methods)
• Nanoparticles (chemistry)
• Nickel (chemistry, therapeutic use)
• Phototherapy (methods)
• Polyethylene Glycols (chemistry)
• Polymers (chemistry)
• Porosity