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B7-H1 Promotes the Functional Effect of Human Gingiva-Derived Mesenchymal Stem Cells on Collagen-Induced Arthritis Murine Model.

Abstract
Recent studies found that mesenchymal stem cells (MSCs), by virtue of their tissue recovery and immunoregulatory properties, have shown a broad prospect for applications in various autoimmune and degenerative diseases. Although the potential therapeutic use of MSCs is considerable, studies and clinical treatment efficacy are preliminary due to the heterogeneity of MSCs. Herein, based on RNA-sequencing (RNA-seq) and single cell sequence properties, we demonstrated that B7-H1 plays an important role in the immunosuppressive function of human gingiva-derived mesenchymal stem cells (GMSCs) in a collagen-induced arthritis murine model that is dependent on STAT3 signaling. Our data offer convincing evidence that B7-H1 expression by GMSCs helps to identify a new subpopulation of MSCs with a greater immunosuppressive property. The approach provides a unique and additional strategy for stem cells-based therapies of autoimmune and other inflammatory diseases.
AuthorsWenbin Wu, Ze Xiu Xiao, Donglan Zeng, Feng Huang, Julie Wang, Yanying Liu, Joseph A Bellanti, Nancy Olsen, Song Guo Zheng
JournalMolecular therapy : the journal of the American Society of Gene Therapy (Mol Ther) Vol. 28 Issue 11 Pg. 2417-2429 (11 04 2020) ISSN: 1525-0024 [Electronic] United States
PMID32707035 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Chemical References
  • B7-H1 Antigen
  • Biomarkers
  • CD274 protein, human
  • STAT3 Transcription Factor
  • Collagen
Topics
  • Animals
  • Arthritis, Experimental (etiology, metabolism, pathology)
  • Autoimmunity
  • B7-H1 Antigen (genetics, metabolism)
  • Biomarkers
  • Collagen (adverse effects)
  • Disease Models, Animal
  • Disease Susceptibility
  • Gingiva (cytology)
  • Humans
  • Mesenchymal Stem Cells (cytology, metabolism)
  • Mice
  • STAT3 Transcription Factor (metabolism)
  • Signal Transduction

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