Alterations in the metabolic networks of temporal lobe epilepsy patients: A graph theoretical analysis using FDG-PET.

Abstract

OBJECTIVE:

The aim of this study is to investigate changes in metabolic networks based on fluorodeoxyglucose positron emission tomography (FDG-PET) in patients with drug-resistant temporal lobe epilepsy (TLE) (with and without hippocampal sclerosis [HS]) when compared with healthy controls.

METHODS:

We retrospectively enrolled 30 patients with drug-resistant temporal lobe epilepsy (17 patients with HS and 13 patients without HS) and 39 healthy controls. All subjects underwent interictal FDG-PET scans, which were analyzed to obtain metabolic connectivity using graph theoretical analysis. We investigated the differences in metabolic connectivity between patients with drug-resistant TLE (with and without HS) and healthy controls.

RESULTS:

When compared with healthy controls, TLE patients with HS showed alterations of global and local metabolic connectivity. When considering global connectivity, TLE patients with HS had a decreased average degree with increased modularity. When considering local connectivity, TLE patients with HS displayed alterations of betweeness centrality in widespread regions. However, there were no alterations of global metabolic connectivity in TLE patients without HS when compared with healthy controls. In addition, when compared to TLE patients without HS, TLE patients with HS had increased modularity.

SIGNIFICANCE:

Our study demonstrates more severe alterations in metabolic networks based on FDG-PET in TLE patients with HS than in those without HS and healthy controls. This may represent distinct epileptic networks in TLE patients with HS versus those without HS, although both are drug-resistant focal epilepsy.

• Authors: Hye-Kyung Shim, Ho-Joon Lee, Sung Eun Kim, Byung In Lee, Seongho Park, Kang Min Park
• Journal: NeuroImage. Clinical (Neuroimage Clin) Vol. 27 Pg. 102349 ( 2020) ISSN: 2213-1582 [Electronic] Netherlands
• PMID: 32702626 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Chemical References

• Fluorodeoxyglucose F18

Topics

• Epilepsy, Temporal Lobe (diagnostic imaging, pathology)
• Fluorodeoxyglucose F18
• Hippocampus (pathology)
• Humans
• Magnetic Resonance Imaging
• Metabolic Networks and Pathways
• Positron-Emission Tomography
• Retrospective Studies
• Sclerosis (pathology)