Abstract | BACKGROUND/AIM: PATIENTS AND METHODS: The standard schedules were compared with two types of schedules, the dose escalation and the short-term schedules. Standard schedules were 60-74 Gy in 30-37 fractions. The dose escalation schedules with hypofractionation and hyperfractionation were 69 Gy in 30 fractions and 69.6 Gy in 58 fractions, respectively, twice per day (b.i.d). The short-term schedules were concomitant boost, 64 Gy in 40 fractions b.i.d. and the accelerated radiotherapy schedule, 57.6 Gy in 36 fractions, three fractions per day (t.i.d). RESULTS: The average TCP for the short-term schedules was more than 16% in two tumor models; however, the TCP for standard and dose escalation schedules was less than 5%. In each organ, the increase in NTCP for the short-term schedule compared with standard schedules was less than 15%. CONCLUSION: The short-term schedules had an advantage over standard schedules for NSCLC.
|
Authors | Yoshihiro Ueda, Osamu Suzuki, Shingo Ohira, Masashi Yagi, Iori Sumida, Kentaro Wada, Shoki Inui, Masaru Isono, Masayoshi Miyazaki, Kazuhiko Ogawa, Teruki Teshima |
Journal | Anticancer research
(Anticancer Res)
Vol. 40
Issue 7
Pg. 4095-4104
(Jul 2020)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 32620658
(Publication Type: Journal Article)
|
Copyright | Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
Topics |
- Algorithms
- Carcinoma, Non-Small-Cell Lung
(pathology, therapy)
- Chemoradiotherapy
(methods)
- Dose Fractionation, Radiation
- Humans
- Lung Neoplasms
(pathology, therapy)
- Neoplasm Staging
|