Abstract | OBJECTIVE: This study assessed the efficacy and safety of biological agents in patients with giant cell arteritis (GCA). MATERIALS AND METHODS: RESULTS: The remission rate was significantly higher for tocilizumab-treated patients than that for placebo-treated controls (odds ratio (OR) 7.009, 95% confidence interval (CI) 3.854 - 12.75, p < 0.001). In addition, the relapse rate was significantly lower for the tocilizumab group than that for the placebo group (OR 0.222, 95% CI 0.129 - 0.381, p < 0.001). Further, no significant difference in remission and relapse was observed between groups treated with TNF inhibitors, abatacept, and placebo. The number of serious adverse events (SAEs) was significantly lower in tocilizumab-treated patients than that in placebo-treated controls (OR 0.539, 95% CI 0.296 - 0.982, p = 0.044). However, there was no significant difference in SAEs among patients treated with TNF inhibitors, abatacept, and placebo. The infection rate was significantly higher in TNF inhibitor-treated patients than in those treated with placebo (OR 2.407, 95% CI 1.168 - 4.960, p = 0.017), while there was no significant difference in infection rate between individuals treated with tocilizumab, abatacept, and placebo. CONCLUSION:
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Authors | Gwan Gyu Song, Young Ho Lee |
Journal | International journal of clinical pharmacology and therapeutics
(Int J Clin Pharmacol Ther)
Vol. 58
Issue 9
Pg. 504-510
(Sep 2020)
ISSN: 0946-1965 [Print] Germany |
PMID | 32567545
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- Antirheumatic Agents
- Biological Factors
- Abatacept
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Topics |
- Abatacept
(adverse effects)
- Antirheumatic Agents
(therapeutic use)
- Biological Factors
(therapeutic use)
- Biological Therapy
- Giant Cell Arteritis
(drug therapy)
- Humans
- Randomized Controlled Trials as Topic
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