Abstract | BACKGROUND: OBJECTIVES: To report the first neuropathological study of ephedrone toxicity. METHODS: The brain of a 33-year-old Ukrainian female ex- ephedrone addict with a long history of l-dopa-unresponsive parkinsonism with dysarthria, dystonia, profound postural instability, cock-gait, and frequent falls, and on antiretroviral treatment, was examined using routine stains and immunohistochemistry. RESULTS: Neuropathological findings included diffuse pallidal astrogliosis without neuronal depletion. There was also widespread vascular pathology with small vessels occluded by foreign material, associated with giant cell response without any evidence of consequent focal infarction and a cerebellar abscess. CONCLUSIONS:
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Authors | Yanosh Sanotsky, Marianna Selikhova, Ludmyla Fedoryshyn, Petro Kuzyk, Yuriy Matviyenko, Orest Semeryak, Dorota Dziewulska, Janice L Holton, Andrew J Lees |
Journal | Movement disorders : official journal of the Movement Disorder Society
(Mov Disord)
Vol. 35
Issue 10
Pg. 1858-1863
(10 2020)
ISSN: 1531-8257 [Electronic] United States |
PMID | 32542919
(Publication Type: Journal Article)
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Copyright | © 2020 International Parkinson and Movement Disorder Society. |
Chemical References |
- Propiophenones
- monomethylpropion
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Topics |
- Adult
- Brain Diseases
- Female
- Humans
- Manganese Poisoning
- Parkinsonian Disorders
(chemically induced)
- Propiophenones
(toxicity)
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