Immunology of COVID-19: Current State of the Science.

Abstract

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.

• Authors: Nicolas Vabret, Graham J Britton, Conor Gruber, Samarth Hegde, Joel Kim, Maria Kuksin, Rachel Levantovsky, Louise Malle, Alvaro Moreira, Matthew D Park, Luisanna Pia, Emma Risson, Miriam Saffern, Bérengère Salomé, Myvizhi Esai Selvan, Matthew P Spindler, Jessica Tan, Verena van der Heide, Jill K Gregory, Konstantina Alexandropoulos, Nina Bhardwaj, Brian D Brown, Benjamin Greenbaum, Zeynep H Gümüş, Dirk Homann, Amir Horowitz, Alice O Kamphorst, Maria A Curotto de Lafaille, Saurabh Mehandru, Miriam Merad, Robert M Samstein, Sinai Immunology Review Project
• Journal: Immunity (Immunity) Vol. 52 Issue 6 Pg. 910-941 (Jun 16 2020) ISSN: 1097-4180 [Electronic] United States
• PMID: 32505227 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Topics

• Animals
• Betacoronavirus (physiology)
• COVID-19
• Coronavirus Infections (diagnosis, immunology, pathology, therapy)
• Disease Susceptibility
• Humans
• Immunity, Innate
• Immunologic Memory
• Inflammation (immunology, virology)
• Lymphocytes (immunology)
• Myeloid Cells (immunology)
• Pandemics
• Pneumonia, Viral (diagnosis, immunology, pathology, therapy)
• SARS-CoV-2