Abstract | OBJECTIVE: Evaluate the effects of carboxy-methyl- beta-glucan on cervical epithelialization and on the vaginal microbiota in patients with HPV infection or low-grade cervical preneoplastic lesion (CIN 1). MATERIALS AND METHODS: Seven-hundred eighty-four women with positive HPV tests or diagnosed with CIN 1 were enrolled in a retrospective case-control study. All the recruited women performed, at baseline and after 6 months, Pap test, HPV test, evaluation of vaginal health according to the Amsel criteria, colposcopy, and punch biopsy. The study population was then divided into 2 groups in relation to the therapy performed during the follow-up period. Group A performed treatment with vaginal gel based on carboxy-methyl- beta-glucan (1 application/day for 20 days per month for 3 months). Group B was the control group. RESULTS: The patients of group A had a significant improvement in the ectopia pattern and a greater number of cases with metaplasia in the maturation phase with a significant increase in Lugol uptake. In the experimental group, a significant improvement in the pH indices, a negative Swift test and a resolution of the leucorrhoea were observed. A negative result of the 37.1% Pap test and the 39.9% HPV test (vs. 15.2% and 16.5%, respectively) were demonstrated in the treatment group with respect to the control group. A negativization of the colposcopic pictures was observed with a reduction in the amount of CIN 1 found higher in the treatment group. CONCLUSIONS: Vaginal therapy based on carboxy-methyl- beta-glucan has been able to improve overall vaginal health; this effect seemed to positively impact the risk of persistence and progression of CIN.
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Authors | Giada Lavitola, Luigi Della Corte, Nicoletta De Rosa, Carmine Nappi, Giuseppe Bifulco |
Journal | BioMed research international
(Biomed Res Int)
Vol. 2020
Pg. 5476389
( 2020)
ISSN: 2314-6141 [Electronic] United States |
PMID | 32420349
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Giada Lavitola et al. |
Chemical References |
- beta-Glucans
- carboxymethyl-beta-1,3-glucan
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Topics |
- Adult
- Case-Control Studies
- Cervix Uteri
(cytology, drug effects)
- Female
- Humans
- Microbiota
(drug effects)
- Papillomavirus Infections
(drug therapy, physiopathology)
- Re-Epithelialization
(drug effects)
- Retrospective Studies
- Vagina
(drug effects, microbiology)
- beta-Glucans
(pharmacology, therapeutic use)
- Uterine Cervical Dysplasia
(drug therapy, physiopathology)
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