Level and Change in N-Terminal Pro-B-Type Natriuretic Peptide and Kidney Function and Survival to Age 90.

Abstract

BACKGROUND:

Many traditional cardiovascular risk factors do not predict survival to very old age. Studies have shown associations of estimated glomerular filtration rate (eGFR) and N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) with cardiovascular disease and mortality in older populations. This study aimed to evaluate the associations of the level and change in eGFR and NT-pro-BNP with longevity to age 90 years.

METHOD:

The population included participants (n = 3,645) in the Cardiovascular Health Study, aged between 67 and 75 at baseline. The main exposures were eGFR, calculated with the Berlin Initiative Study (BIS) 2 equation, and NT-pro-BNP, and the main outcome was survival to age 90. Mixed models were used to estimate level and change of the main exposures.

RESULTS:

There was an association between baseline level and change of both eGFR and NT-pro-BNP and survival to 90, and this association persisted after adjustment for covariates. Each 10 mL/min/1.73 m2 higher eGFR level was associated with an adjusted odds ratio (OR) of 1.23 (95% CI: 1.13, 1.34) of survival to 90, and a 0.5 mL/min/1.73 m2 slower decline in eGFR was associated with an OR of 1.51 (95% CI: 1.31, 1.74). A twofold higher level of NT-pro-BNP level had an adjusted OR of 0.67 (95% CI: 0.61, 0.73), and a 1.05-fold increase per year in NT-pro-BNP had an OR of 0.53 (95% CI: 0.43, 0.65) for survival to age 90.

CONCLUSION:

eGFR and NT-pro-BNP appear to be important risk factors for longevity to age 90.

• Authors: Astrid D Häberle, Mary L Biggs, Mary Cushman, Bruce M Psaty, Anne B Newman, Michael G Shlipak, John Gottdiener, Chenkai Wu, Julius M Gardin, Nisha Bansal, Michelle C Odden
• Journal: The journals of gerontology. Series A, Biological sciences and medical sciences (J Gerontol A Biol Sci Med Sci) Vol. 76 Issue 3 Pg. 478-484 (02 25 2021) ISSN: 1758-535X [Electronic] United States
• PMID: 32417919 (Publication Type: Journal Article, Observational Study, Research Support, N.I.H., Extramural)
• Copyright: © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• Biomarkers
• Peptide Fragments
• pro-brain natriuretic peptide (1-76)
• Natriuretic Peptide, Brain

Topics

• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Cardiovascular Diseases (blood, diagnosis, epidemiology)
• Cohort Studies
• Female
• Glomerular Filtration Rate (physiology)
• Humans
• Kidney Diseases (blood, diagnosis, epidemiology)
• Longevity
• Male
• Natriuretic Peptide, Brain (blood)
• Odds Ratio
• Peptide Fragments (blood)
• Risk Factors
• Survival Rate