The First Report of Macrolide-Resistant Bordetella pertussis Isolation in Japan.

Abstract

We report the first detection of a macrolide-resistant Bordetella pertussis strain in Japan. The isolate was highly resistant to the macrolides (minimum inhibitory concentrations for erythromycin and clarithromycin: > 256 µg/ml, for azithromycin: 32 µg/ml) and A2047G mutation was identified in the 23S rRNA. The Multilocus Sequence Typing and Multilocus Variable Number of Tandem Repeat Analysis genotypes of this isolate were MT195 and ptxP1/ptxA1/prn1/fim3A/fhaB3, respectively, suggesting a relationship with the macrolide-resistant B. pertussis lineage currently found in China. This raises the possibility that macrolide-resistant B. pertussis has already fully spread in Japan. For a better control of B. pertussis infections, the surveillance for macrolide-resistant B. pertussis is essential in not only Japan, but also other Asian countries.

• Authors: Takahiro Yamaguchi, Yasuhiro Kawasaki, Chihiro Katsukawa, Ryuji Kawahara, Kentaro Kawatsu
• Journal: Japanese journal of infectious diseases (Jpn J Infect Dis) Vol. 73 Issue 5 Pg. 361-362 (Sep 24 2020) ISSN: 1884-2836 [Electronic] Japan
• PMID: 32350216 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Macrolides
• RNA, Ribosomal, 23S
• Erythromycin
• Azithromycin
• Clarithromycin

Topics

• Anti-Bacterial Agents (administration & dosage)
• Azithromycin (administration & dosage)
• Bordetella pertussis (drug effects, genetics)
• Clarithromycin (administration & dosage)
• Drug Resistance, Bacterial (genetics)
• Erythromycin (administration & dosage)
• Genotype
• Humans
• Infant
• Japan
• Macrolides (administration & dosage)
• Male
• Microbial Sensitivity Tests
• Multilocus Sequence Typing
• Mutation
• RNA, Ribosomal, 23S (genetics)
• Whooping Cough (drug therapy, microbiology)