Partial Synthesis of Crassicauline A from Yunaconitine.

Abstract

Both Aconitum hemsleyanum and Aconitum geniculatun have abundant contents of yunaconitine (1). Yunaconitine (1) has similar skeleton to crassicauline A (3); the only difference between them is that 1 contains a α-hydroxyl group at C-3. Our team attempts to convert 1 into 3 because 3 owns pharmacological activity. There are two steps to achieve the transformation above: firstly, use dehydration reaction to transform yunaconitine (1) into dehydroyunaconitine (2); secondly, use hydrogen reduction to acquire crassicauline A (3). Compared with other methods, this one below is more suitable for production application and more concise; moreover, the cost is lower with higher yield.

• Authors: Rong-Ping Zhang, Yan-Jun Lin, Hao-Fei Yu, Si-Ying Chen, Jun Zhou
• Journal: Natural products and bioprospecting (Nat Prod Bioprospect) Vol. 10 Issue 2 Pg. 105-108 (Apr 2020) ISSN: 2192-2195 [Print] Germany
• PMID: 32297141 (Publication Type: Journal Article)