Antimicrobial resistance comparison of Klebsiella pneumoniae pathogens isolated from intra-abdominal and urinary tract infections in different organs, hospital departments and regions of China between 2014 and 2017.

Abstract

BACKGROUND:

We describe antibiotic resistance trends of Klebsiella pneumoniae pathogens, responsible for urinary tract infections (UTIs) and intra-abdominal infections (IAIs), isolated from different organs and tissues, hospital departments and Chinese regions between 2014 and 2017.

METHODS:

Resistances of UTIs and IAIs derived K. pneumoniae isolates from 17 hospitals in 7 Chinese regions to amikacin, imipenem, piperacillin-tazobactam, ertapenem, and cefepime were unequivocally established.

RESULTS:

Overall resistance rates of K. pneumoniae IAI isolates obtained from gallbladder and abscesses increased to amikacin (14.29-30.95%) and for liver, gallbladder, and abscesses to imipenem (14.29-38.10%), piperacillin-tazobactam (23.81-38.10%), and ertapenem (23.81-38.10%) in 2017, but were constant (20-30%) for K. pneumoniae isolates from UTIs from 2014 to 2017. In medical and surgical ICUs, resistance rates to all tested antibiotics rose to ∼60% for IAIs, which was also reflected in higher resistance rates of hospital acquired (HA) compared to community acquired (CA) infections. In medical ICUs resistance rates increased to 50-60% for amikacin, imipenem, and ertapenem for UTI-derived K. pneumoniae isolates in 2017. Resistance rates to all tested antibiotics were highest in the east Jiangzhe region of China, being ∼60% for K. pneumoniae isolates from IAIs and 40% for K. pneumoniae isolates from UTIs to ertapenem and imipenem, as well as > 40% for piperacillin-tazobactam in 2017.

CONCLUSION:

In China, ICUs resistance rates to K. pneumoniae IAIs and UTIs isolates was increased in 2017 for all tested antimicrobials including carbapenems, which makes them no longer suitable for empiric treatment. In the east Jiangzhe region this was a general trend that was independent of the type of hospital department.

• Authors: Hui Zhang, Ge Zhang, Yang Yang, Jingjia Zhang, Dongxue Li, Simeng Duan, Qiwen Yang, Yingchun Xu
• Journal: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi (J Microbiol Immunol Infect) Vol. 54 Issue 4 Pg. 639-648 (Aug 2021) ISSN: 1995-9133 [Electronic] England
• PMID: 32247662 (Publication Type: Comparative Study, Journal Article, Multicenter Study)
• Copyright: Copyright © 2020. Published by Elsevier B.V.

Topics

• China (epidemiology)
• Community-Acquired Infections (epidemiology, microbiology)
• Cross Infection (epidemiology, microbiology)
• Drug Resistance, Bacterial
• Hospital Departments (statistics & numerical data)
• Humans
• Intraabdominal Infections (microbiology)
• Klebsiella Infections (epidemiology, microbiology, urine)
• Klebsiella pneumoniae (drug effects, isolation & purification, pathogenicity)
• Microbial Sensitivity Tests
• Urinary Tract Infections (microbiology)