Electrospun chitosan membranes containing bioactive and therapeutic agents for enhanced wound healing.

Abstract

Electrospinning is one of the most promising techniques for generating porous, nonwoven, and submicron fiber-based membranes for various applications such as catalysis, sensing, tissue engineering and wound healing. Wide range of biopolymers including chitosan can be used to generate submicron fibrous membranes. Owing to the extra cellular matrix (ECM) mimicking property, exudate uptake capacity, biocompatibility, antibacterial activity and biodegradability, electrospun membranes based on chitosan loaded with biologically active agents can play important role in wound healing applications. In order to improve the mechanical stability, degradation, antimicrobial property, vascularization potential and wound healing capacity, various active components such as other polymers, therapeutic agents, nanoparticles and biomolecules were introduced. Approaches such as coaxial electrospinning with other polymers have also been tried to improve the properties of chitosan membranes. To improve the mechanical stability under in vivo conditions, various crosslinking strategies ranging from physical, chemical and biological approaches were also tried by researchers. Electrospun chitosan meshes have also been designed in a highly specialized manner with specific functionalities to deal with the challenging wound environment of diabetic and burn wounds. This review provides a detailed overview of electrospun chitosan-based membranes containing various bioactive and therapeutic agents in the perspective of wound healing and skin regeneration.

• Authors: Robin Augustine, Syed Raza Ur Rehman, Rashid Ahmed, Alap Ali Zahid, Majid Sharifi, Mojtaba Falahati, Anwarul Hasan
• Journal: International journal of biological macromolecules (Int J Biol Macromol) Vol. 156 Pg. 153-170 (Aug 01 2020) ISSN: 1879-0003 [Electronic] Netherlands
• PMID: 32229203 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020. Published by Elsevier B.V.

Chemical References

• Biocompatible Materials
• Membranes, Artificial
• Chitosan

Topics

• Biocompatible Materials (chemical synthesis, chemistry)
• Chitosan (chemistry, isolation & purification, therapeutic use)
• Electrochemical Techniques
• Humans
• Membranes, Artificial
• Nanofibers (chemistry, poisoning, therapeutic use)
• Wound Healing
• Wounds and Injuries (drug therapy)