Role of innate and adaptive immunity in the efficacy of anti-HER2 monoclonal antibodies for HER2-positive breast cancer.

Abstract

Anti-HER2 monoclonal antibodies (mAbs) such as trastuzumab are effective for all stages of HER2-positive breast cancer (BC). However, intrinsic or acquired resistance to these drugs may occur in a significant number of patients (pts) and, except for HER2 status, no validated predictive factors of response/resistance have been identified to date. This lack is in part due to the not yet fully elucidated mechanism of action of mAbs in vivo. Increasing evidence suggests a significant contribution of both innate and adaptive immunity to the antitumor effects of mAbs. The aim of this review was to describe the role of innate and adaptive immunity in the efficacy of anti-HER2 mAbs and to report known and novel strategies to be used for optimizing immune effects of anti-HER2 therapies for HER2-positive BC.

• Authors: Antonino Musolino, Daniela Boggiani, Benedetta Pellegrino, Daniele Zanoni, Angelica Sikokis, Gabriele Missale, Enrico Maria Silini, Giuseppe Maglietta, Antonio Frassoldati, Maria Michiara
• Journal: Critical reviews in oncology/hematology (Crit Rev Oncol Hematol) Vol. 149 Pg. 102927 (May 2020) ISSN: 1879-0461 [Electronic] Netherlands
• PMID: 32172224 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Antineoplastic Agents
• Receptor, ErbB-2
• Trastuzumab

Topics

• Adaptive Immunity
• Antibodies, Monoclonal (chemistry, therapeutic use)
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Antineoplastic Agents (therapeutic use)
• Breast Neoplasms (drug therapy, immunology)
• Humans
• Receptor, ErbB-2 (antagonists & inhibitors, chemistry)
• Trastuzumab (therapeutic use)