Abstract | PURPOSE: PATIENTS AND METHODS: RESULTS: AHmDN exhibited strong stability, remarkable cytotoxicity and higher uptake to tumor cells. Cell imaging analysis indicated that DOX was separated from AHmDN and uniformly distributed in cell nucleus while mPPZ localized in cytoplasm. The PDT activity of all the samples had been confirmed by the detection of intracellular ROS. In animal experiments, AHmDN was demonstrated to have a prominent tumor-targeting effect using a 3D imaging system. In addition, the enhanced antitumor effect of AHmDN in tumor-bearing mice was also been observed. Importantly, the tumor-targeting effect of such nanoparticles lasted for about 14 days after one injection. CONCLUSION:
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Authors | Ke Zheng, Hongyan Liu, Xinxin Liu, Ying Wang, Linlin Li, Shijie Li, Jinping Xue, Mingdong Huang |
Journal | International journal of nanomedicine
(Int J Nanomedicine)
Vol. 15
Pg. 151-167
( 2020)
ISSN: 1178-2013 [Electronic] New Zealand |
PMID | 32021171
(Publication Type: Journal Article)
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Copyright | © 2020 Zheng et al. |
Chemical References |
- Drug Carriers
- Photosensitizing Agents
- Reactive Oxygen Species
- Recombinant Fusion Proteins
- Doxorubicin
- Paclitaxel
- Serum Albumin, Human
|
Topics |
- Animals
- Apoptosis
(drug effects)
- Cytoplasm
(drug effects)
- Doxorubicin
(administration & dosage, pharmacokinetics)
- Drug Carriers
(administration & dosage, chemistry)
- Female
- Humans
- Liver Neoplasms, Experimental
(diagnostic imaging, drug therapy)
- Mice
- Nanoparticles
(chemistry)
- Neoplasms
(drug therapy)
- Paclitaxel
(administration & dosage, pharmacokinetics)
- Photochemotherapy
(methods)
- Photosensitizing Agents
(administration & dosage, chemistry)
- Reactive Oxygen Species
(metabolism)
- Recombinant Fusion Proteins
(chemistry, metabolism)
- Serum Albumin, Human
(chemistry)
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